Two-time former champions Benfica beat Mitjylland 3-1 on Tuesday to win 7-2 on aggregate and reach the final Champions League qualifying play-off round.
Young midfielder Enzo Fernandez and 20-year-old striker Henrique Araujo scored before Pione Sisto responded for the Danes.
Argentinian Fernandez, 21, and Araujo were making just their second European appearances as Diogo Goncalves claimed the third for the 1961 and 1962 winners.
Earlier, Moldovans Sheriff Tiraspol, who stunned Real Madrid at the Santiago Bernabeu during last season’s group stages, were knocked out by Viktoria Plzen as the Czech outfit won 4-2 on aggregate.
Later, Scottish side Rangers defeated Teddy Teuma’s Union Saint-Gilloise 3-0 as the Belgian outfit drop in the UEFA Europa League.
PSV Eindhoven defeated Monaco 3-2 after extra-time while Dynamo Kiyv also needed the extra 30 minutes to dispatch of Sturm Graz.
The first leg of the play-offs take place on August 16 with the return fixtures eighth days later.
